Oxycodone is an anesthetic, a semi-synthetic opioid derived from thebaine. It was developed in 1916 in Germany. It was one of several new semi-synthetic opioids to improve existing opioids: morphine, diacetylmorphine (heroin), and codeine. Oxycodone is usually prescribed to relieve moderate or severe pain. Oxycodone is a solid, although there are forms in the form of solutions, capsules. Soluble in ethyl alcohol, chloroform, insoluble in water and diethyl ether. Oxycodone hydrochloride dissolves in the following proportions: water is insoluble
- ethanol – 1:60
- chloroform-1: 600
- diethyl ether – insoluble
Oxycodone is obtained from natural sources of opioids by synthesis through thebaine. The main reaction for obtaining oxycodone is the Diels-Alder reaction.
After repeated administration of the drug, a physical and psychological dependence arises  . In case of abuse, symptoms of poisoning are like taking codeine. Oxycodone can only partially suppress withdrawal symptoms in people taking any other drug. Oxycodone can enter the placenta, and is also found in small doses in breast milk. However, there were no inherent pathological changes in newborns. Among the metabolic products is noroxycodone, however, the metabolism of oxycodone itself has not been studied enough, as well as other semi-synthetic opiates.
Duration of action and symptoms of poisoning
When oxycodone is administered orally:
- its effect begins in 10-15 minutes;
- the maximum effect comes in 30-60 minutes;
- the total duration of action is from 3 to 6 hours.
The toxic range is from 0.6 to 10 mg / ml. When intoxication, respiratory depression, bradycardia, syncope, drowsiness, euphoria/dysphoria, disorientation, nausea, vomiting, miosis, urinary retention are observed. On the skin, there may be rashes, hives and itchy skin. A person can fall into a coma, there will be an arrhythmia, an acidosis. In extreme cases, intoxication can lead to vascular insufficiency and to cardiac arrest, after which death occurs.
Oxycodone is used as an anesthetic in combination with aspirin or paracetamol. It is used as an anesthetic, which is a substitute for morphine, diamorphine or hydrocodone. Oxycodone is not used as an antitussive. Effective for acute pain. Also used in oncology.
Uses Of ROxycontin (Oxycontin)
Oxycodone is a pure opioid agonist with an analgesic effect. This class of substances includes morphine, heroin, hydromorphone or hydrocodone. Pharmacological actions of Oxycontin include reduction of anxiety symptoms, a sense of euphoria and relief of pain. The analgesic effect increases with increasing dose, for drugs like oxycin, there is no definite maximum dose. The maximum effective dose of an analgesic is determined when side effects occur. Oxycontin can cause physical and psychological dependence, so the drug can be bought at the pharmacy solely on the prescribed prescription.
- OxyContin tablets are taken at 12-hour intervals. The dosage depends on the severity of the pain, the patient’s history and the need for anesthesia.
- The usual starting dose for patients who have not previously taken opioids or patients with severe pain that is not controlled by weaker drugs is 10 mg every 12 hours.
- As necessary, the dose is gradually increased by 25% – 50%, and it is absolutely necessary to follow the instructions for oxycontin at the same time. For most patients, the maximum dose is 200 mg for 12 hours. But sometimes patients need higher doses, which is determined by the need for appointing emergency analgesic therapy more than 2 times a day.
- The correct dosage for each individual patient is a dose that allows you to control pain and is well tolerated for 12 hours.
- Also, the dose of the drug may increase over time due to increased pain, the development of a new pain syndrome and / or the emergence of resistance to the analgesic.• Oxycodone is not prescribed as an anesthetic as needed.
• OxyContin/oxycodone tablets are swallowed whole. Do not break, chew, or crumbleAs this results in the rapid release and absorption of a potentially lethal dose of oxycodone. It should be clearly remembered that a total daily dose of more than 80 mg can lead to lethal effects of respiratory depression in patients who do not have resistance to opioids, so it is strictly forbidden to transfer the drug to other people. This can have serious medical consequences, including death. Therefore, deciding to buy Oxycontin, consider possible options for safe storage of the drug away from children and strangers who may abuse the medicine.
- OxyContin is prescribed for relief of moderate-severe pain when anesthesia therapy is required for the patient around the clock for a long period of time.
- To alleviate moderate and severe pain in patients with cancer and post-operative pain.
For the treatment of severe pain, requiring the appointment of a strong opioid.
OxyContin in a dose of 60 mg, 80 mg, and 160 mg or in a single dose of more than 40 mg is used only in patients who developed resistance to opioid drugs.
- OxyContin is not prescribed for pain relief in the period immediately after surgery (the first 12-24 hours after surgery) or for the treatment of mild or short-term pain.
- Hypersensitivity to oxycodone or other ingredients of the drug.
- Oxycodone is not prescribed in situations where opioids are contraindicated: severe respiratory depression with hypoxia, paralytic intestinal obstruction, acute abdominal pain, delayed gastric emptying, severe chronic obstructive pulmonary disease, pulmonary heart disease, severe bronchial asthma, elevated carbon dioxide concentrations in the blood, moderate – Severe dysfunction of the liver, chronic constipation.
- Patients with rare congenital problems of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome.
• Like all drugs, (hydr)oxycontin can lead to side effects:
• weight loss
• anxiety, confusion, depression, insomnia, nervousness, unusual thoughts and dreams
• drowsiness, dizziness, headache, tremor, retardation, sedation.
• shortness of breath, bronchospasm, decreased cough reflex, respiratory depression.
• constipation, nausea, vomiting, abdominal pain, diarrhea, dry mouth, indigestion.
• itching, rash, hyperhidrosis.
• asthenia, fatigue.